Between Clouds is a colorful, biopunk, tabletop RPG about a family of misfits navigating the open skies atop their beloved flying beast. Life among the clouds revolves around the Kirin, oversized animals that possess volatile genetics and the gift of flight. The presence of these creatures can strengthen entire ecosystems, yet humans poach the Kirin to keep their airborne cities aloft. With an uninhabitable surface below, humanity must learn to coexist with the flora and fauna of their airborne realm or perish.

In Between Clouds players assume the role of Symbiotes, rare outcasts who have formed unbreakable bonds with a Kirin. Few are ever approached by the flying beasts, and fewer still head the call. Those who do lead nomadic lives. They travel across Empyrea atop their airborne companions, making allies and enemies along the way, all while striving to help those in need and protect the wild Kirin that they encounter. Symbiotes are transformed by their Kirin, being granted bestial mutations and biological powers as a result of their bond.

A group of Symbiotes bound to a single Kirin is referred to as a family, usually consisting of three to five members. In their former lives most Symbiotes were rejected by society for being too unusual, but with their found Family each person can find a sense of community and belonging that allows them to truly flourish. As a group, the Symbiotes must rely on each other and their Kirin to succeed. To carry the family, Kirin are equipped with a saddle, a mobile home that Symbiotes use to travel, eat, and rest.